I went last year just as an excuse to hit the strip, but I was not aware about the Cashman Center being in a not-so-glitzy part of town. I had a good time, and I can give this year's Anime Vegas a benefit of a doubt since it will be at a hotel location that's close to the strip (MGM side, I assume?).
I do appreciate the number of voice acting related panels. I recommend this con for anyone who wants to work in anime localization field. Great networking opportunities! I'm really hoping there are more panel rooms this year. Two live programming rooms for panels is not enough!
We'll see how this year goes with the new location. I'm an optimist, so I'm keeping my fingers crossed.
EDIT: You can read a much more in depth review of my Anime Vegas experience on my final thoughts section in our con report: