I'll add a "don't" to the list:
DON'T do skits based on internet memes! The thing with internet memes is that they have a VERY short shelf life before people start getting tired of them and they lose their edginess, relevance, whatever. Case in point- Grumpy Cat's been a thing for what now? A week? Within a couple of days I was SO FREAKING SICK of seeing that animal's face posted multiple times all over my facebook feed that finally I asked "Is anyone else over this already? Getting sick of seeing it all over my page!"