3 girls and 1 guy? It would help to know your general interests.
* Snow/Sazh + any combo of Lightning/Serah/Vanille/Fang/etc from FFXIII. FFXIII and its successor have a predominantly female cast
* Snow/Hope/Sazh/Noel/Caius + any combo of Lightning/Serah/Yeul/Lebreau/etc.
* Cloud (or another guy) + Tifa/Aerith/Yuffie
* Squall (or another guy) + Rinoa/Quistis/Selphy
* Zidane (or another guy) + Garnet/Beatrix
* Tidus (or another guy) + Yuna/Rikku/Lulu (or Paine)
* Link + Zelda/Ruto/Malon/Midna
* Kyon + Haruhi/Yuki/Mikuru
* Kaname/Zero + Yuuki/Ruka/Rima/Maria (pick 3 Cross Academy girls!)
* Otonashi + Yuri/Kanade/Yui/etc
* Kouichi + Mei/Izumi/another girl
* Naruto + Sakura/Hinata/another girl
* Luffy + Nico Robin/Boa Hancock/Nami
* Ichigo + Rukia/Orihime/Nelliel/etc
* Light + Misa/Kiyomi/Sayu (admittedly, this would not stand out much)
* Male Vocaloid + 3 Female Vocaloids. The options here are unlimited.
* Lelouch + CC/Shirley/Nunnally/etc.]
* Gundam is a long-running franchise with TONS of options.
* Male from Fairy Tail + Lucy/Erza/Mirajane/etc.
* Briefers + Panty/Stocking/Kneesocks/Scanty/etc.
* Puella Magi Madoka Magica has a predominantly female cast. No male character is anything more than fleshed-out furniture, but there are males.
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