This'll be my 4th time going to NDK, and my 3rd time going to their newer location. It's in downtown Denver, and it's right next to an outdoor pedestrian mall. If you plan to eat around that area, you can take the free 16th Street Mall shuttle, which will make stops at every intersection of the mall. You -might- want comfy shoes for this, though I've walked and shuttled around in heels fine...sort of.
The con is separated out into 2 parts of the hotel. Last year, one was designated for shoots, dealer's room, and gaming. The other one was for main events/panels and artist's alley. These two parts are connected by a sky bridge, and NDK staff get super antsy if you stand around on the bridge or take pictures on it at any time.
Also, since Colorado's pretty dry, I highly advise getting a water bottle and bringing it around. There's going to be water stations all around the con, but it won't hurt to have some with you in case if those run out.
As far as shoots go...I unfortunately have no clue. It's been a mess since they closed down the old NDK forums a couple of years back. All I can say is to carefully watch the official Facebook NDK page
or the event page
--both the official posts made by the group and visitor/guests posts.
Hope to see you there!